We have a current opportunity for a Director, DMPK on a permanent basis. For further information about this position please apply.
As the Director of DMPK, you will supervise ADME scientists locally in Boston who provide drug discovery and development support for our diverse portfolio including; small molecules, biologics, nano-medicines and PROTACs. In addition, the selected individual will also have the opportunity to provide input into drug discovery and development across the global Oncology portfolio.
Responsibilities:
- Supervising and managing a team of ADME scientists by mentoring and challenging them, as well as providing expert advice and context for the interpretation of complex data.
- Developing and implementing state-of-the-art technologies in the field of drug metabolism and transporters.
- Leading DMPK-related compound design activities to ensure project ADME challenges are thoroughly assessed and resolved from HTS work-up to candidate nomination through risk mitigation and/or structural modification.
- Applying an expert understanding of DMPK, physico-chemical property assays and/or biotransformation reactions to discovery project chemistry and data.
Requirements:
- PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery, or a higher degree in a research area relevant to DMPK science.
- At least 8+ years of relevant industry experience in ADME/Project Representation or a MS degree with at least 13+ years of relevant industry experience.
- Strong technical knowledge of DMPK science with a proven ability to delineate the impact of chemical structure on measured properties.
